metabolic acidosis in patients taking the antiepileptic, zonisamide (Zonegran, etc)

April 2009

You'll see a new warning about metabolic acidosis in patients taking the antiepileptic, zonisamide (Zonegran, etc).

This is similar to the warning about metabolic acidosis with topiramate (Topamax, etc).

Zonisamide and topiramate are carbonic anhydrase inhibitors. This increases bicarb excretion and can lead to metabolic acidosis.

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