Guide Safe Use of Alteplase for Catheter-Directed Thrombolysis

April 2021

Questions are cropping up about catheter-directed thrombolysis (CDT) for deep vein thrombosis (DVT) or pulmonary embolism (PE).

Patients undergoing CDT will get a thrombolytic and a systemic anticoagulant...usually alteplase plus an IV heparin infusion.

A catheter system (AngioJet, EKOS, etc) delivers the thrombolytic locally into the clot to dissolve it...the anticoagulant reduces risk of clot extension.

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