serotonin syndrome in HIV patients taking both Prozac (fluoxetine) and Norvir (ritonavir)

September 2001

There are now reports of serotonin syndrome in HIV patients taking both Prozac (fluoxetine) and Norvir (ritonavir).

Norvir is a potent inhibitor of cytochrome P450 enzymes... and can slow the metabolism of Prozac.

This could lead to confusion, muscle spasms, tremor, fever, unusual nausea, abdominal pain, anxiety, etc.

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