Watch for Hypoglycemia in Patients Taking Repaglinide Plus Clopidogrel

October 2015

You'll hear about a potentially dangerous interaction between clopidogrel (Plavix, etc) and repaglinide (Prandin, etc).

We usually think of clopidogrel as a CYP2C19 substrate. But clopidogrel also INHIBITS CYP2C8...causing repaglinide levels to increase.

In fact, clopidogrel can raise repaglinide levels by over 5-fold...and may lead to significant hypoglycemia.

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