Don't Routinely Recommend Praluent for High Cholesterol

September 2015

Praluent (PRAL-you-ent, alirocumab) is the first "PCSK9 inhibitor" for high cholesterol.

It works by preventing PCSK9...proprotein convertase subtilisin kexin type 9...from binding and degrading liver LDL receptors. This leads to more LDL receptors...and more LDL cholesterol clearing from the blood.

Praluent can lower LDL by about 60%, regardless of statin use.

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