Don't Jump to Potassium Binders When ACEIs or ARBs Cause Hyperkalemia

April 2019

New Rx Lokelma (loh-KEL-mah) will pique interest in the role of potassium binders to treat CHRONIC high potassium due to ACEIs or ARBs.

Think of Lokelma (sodium zirconium cyclosilicate) as most similar to sodium polystyrene sulfonate (Kayexalate, etc) for hyperkalemia.

Both exchange sodium to bind potassium...Lokelma also exchanges hydrogen. But Lokelma may cause fewer GI side effects.

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