Unpack the Evidence Behind Leucovorin for Autism and “CFD”

November 2025

Patients are asking about using leucovorin to treat autism.

We know po leucovorin (folinic acid) is FDA-approved to counteract methotrexate toxicity when treating cancer, autoimmune disorders, etc.

But FDA recently approved leucovorin tabs for patients with cerebral folate deficiency (CFD), stirring up questions about using it for autism.

Get concise advice on drug therapy, plus unlimited access to CE

Pharmacist's Letter membership benefits include:

  • 12 issues every year — what you need to know and do, right now
  • Quick, practical reference charts and tools
  • Comprehensive CE library to meet license renewal and state requirements
  • Multiple course formats including live webinars, podcasts, and CE-in-the-Letter to match your learning style
  • Plus much more!

Choose the right tier for your needs today.

Already a subscriber? Log in

Volume pricing available. Get a quote