Erythromycin can interact with the calcium channel blocker felodipine (Plendil)

October 1996

Erythromycin can interact with the calcium channel blocker felodipine (Plendil).

Erythromycin tends to DOUBLE felodipine levels...by inhibiting felodipine metabolism in the liver.

This is important because high levels of felodipine can cause edema...palpitations...flushing...and hypotension.

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